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KMID : 0032220120240010090
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Annals of Dermatology
2012 Volume.24 No. 1 p.90 ~ p.93
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A Simple Assay Method for Melanosome Transfer
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Choi Hye-Ryung
Park So-Hee
Choi Jae-Woo
Kim Dong-Seok
Park Kyung-Chan
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Abstract
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Pigmentation is induced by production of melanin in specialized organelles termed melanosomes and by transfer of these organelles from melanocytes to surrounding keratinocytes. The chemical basis of melanogenesis is relatively well known but the mechanism of melanosome transfer is not well studied. Various pigmentary disorders and cosmetic applications require the use of depigmenting agents. Currently available topical agents used for the reduction of pigmentation mainly include tyrosinase inhibitors and/or melanocyte-cytotoxic agents. Recently, several agents have been introduced to inhibit melanosome transfer from melanocytes to keratinocytes. However, an experimental model for melanosome transfer is not well established. In this study, a simple assay method using flow cytometry is described. (Ann Dermatol 24(1) 90∼93, 2012)
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KEYWORD
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Flow cytometry, Melanosome, Pigmentation, Transfer
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